Title of article
Biological activities of α-mangostin derivatives against acidic sphingomyelinase
Author/Authors
Motoko Hamada، نويسنده , , Kazuhiko Iikubo، نويسنده , , Yuichi Ishikawa، نويسنده , , Aya Ikeda، نويسنده , , Kazuo Umezawa، نويسنده , , Shigeru Nishiyama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
3151
To page
3153
Abstract
Deprenyl and benzofenone-type congeners of α-mangostin 1 have been synthesized to understand their role for the inhibitory activity against sphingomyelinase (SMase). While removal of the prenyl group of the right side (11 and 12) caused loss of the selectivity between ASMase (acidic sphingomyelinase) and NSMase (neutral sphingomyelinase), the prenyl group of the left side appeared to increase the inhibitory activities (16 and 17).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793527
Link To Document