Title of article :
1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists
Author/Authors :
Alexander Alanine، نويسنده , , Anne Bourson، نويسنده , , Bernd Büttelmann، نويسنده , , Ramanjit Gill، نويسنده , , Marie-Paule Heitz، نويسنده , , Vincent Mutel، نويسنده , , Emmanuel Pinard، نويسنده , , Gerhard Trube، نويسنده , , René Wyler، نويسنده ,
Abstract :
Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B subtype selective NMDA receptor antagonist. The structure–activity relationships developed in this series resulted in the discovery of a novel class of potent and selective NMDA receptor blockers displaying activity in vivo.
