Author/Authors :
Nguyen Thanh Lam، نويسنده , , Taotao Ling، نويسنده , , Chinmay Chowdhury، نويسنده , , Ta-Hsiang Chao، نويسنده , , F. R. Bahjat، نويسنده , , G. K. Lloyd، نويسنده , , Lyle L. Moldawer، نويسنده , , Michael A. Palladino، نويسنده , , Emmanuel A. Theodorakis، نويسنده ,
Abstract :
The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-α synthesis and displayed good specificity in suppressing cytokine expression.
