Author/Authors :
Michael A. Letavic، نويسنده , , John T. Barberia، نويسنده , , Thomas J. Carty، نويسنده , , Joel R. Hardink، نويسنده , , Jennifer Liras، نويسنده , , Lori L. Lopresti-Morrow، نويسنده , , Peter G. Mitchell، نويسنده , , Mark C. Noe، نويسنده , , Lisa M. Reeves، نويسنده , , Sheri L. Snow، نويسنده , , Ethan J. Stam، نويسنده , , Francis J. Sweeney، نويسنده , , Marcie L. Vaughn، نويسنده , , Chul H. Yu، نويسنده ,
Abstract :
A series of novel MMP-13 and TNF-α converting enzyme inhibitors based on piperazine 2-hydroxamic acid scaffolds are described. The TACE, MMP-1 and MMP-13 activity of these inhibitors as well as the effect of substitution of the piperazine nitrogen and the P-1′ benzyloxy tailpiece is discussed. Moderate in vivo activity is observed with several members of this group
