Title of article
Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression
Author/Authors
Lorraine Axford، نويسنده , , John R. Boot، نويسنده , , Terrence M. Hotten، نويسنده , , Martine Keenan، نويسنده , , Fionna M. Martin، نويسنده , , Sandra Milutinovic، نويسنده , , Nick A. Moore، نويسنده , , Michael F. OʹNeill، نويسنده , , Ian A. Pullar، نويسنده , , David E. Tupper، نويسنده , , Kristel R. Van Belle، نويسنده , , Vincent Vivien، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3277
To page
3280
Abstract
A series of substituted naphthyl containing chiral [2.2.1] bicycloheptanes were prepared utilizing asymmetric Diels–Alder chemistry. This paper describes structure–activity relationships in this series. The N-methyl 2-naphthyl analogue (16d) and its des-methyl analogue (17d) are active triple re-uptake inhibitors both in vivo and in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793552
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