Author/Authors :
Anthony Boitano، نويسنده , , Cory D. Emal، نويسنده , , Francesco Leonetti، نويسنده , , Neal B. Blatt، نويسنده , , Thomas A. Dineen، نويسنده , , Jonathan A. Ellman، نويسنده , , William R. Roush.، نويسنده , , Anthony W. Opipari Jr.، نويسنده , , Gary D. ، نويسنده ,
Abstract :
Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.
