Author/Authors :
Ayako Yamashita، نويسنده , , Emily Norton، نويسنده , , Peter J. Petersen، نويسنده , , Beth A. Rasmussen، نويسنده , , Guy Singh، نويسنده , , Youjin Yang، نويسنده , , Tarek S. Mansour، نويسنده , , Douglas M. Ho، نويسنده ,
Abstract :
A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.
