Title of article :
Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
Author/Authors :
Bin Ye، نويسنده , , Shawn Bauer، نويسنده , , Brad O. Buckman، نويسنده , , Ameen Ghannam، نويسنده , , Brian D. Griedel، نويسنده , , Seock-Kyu Khim، نويسنده , , Wheeseong Lee، نويسنده , , Karna L. Sacchi، نويسنده , , Kenneth J. Shaw، نويسنده , , Amy Liang، نويسنده , , Qingyu Wu، نويسنده , , Zuchun Zhao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
5
From page :
3361
To page :
3365
Abstract :
Compound 1 was identified by high throughput screening as a novel PAI-1 inhibitor. Optimization of the B and C-segments of 1 resulted in a series of structurally simplified compounds with improved potency. The synthesis and SAR data of these compounds are presented here.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2003
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
793570
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=793570
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