Title of article
Synthesis and biological evaluation of thymine nucleosides fused with 3′,4′-tetrahydrofuran ring
Author/Authors
Myong Jung Kim، نويسنده , , Hea Ok Kim، نويسنده , , Hee-Doo Kim، نويسنده , , Joong Hyup Kim، نويسنده , , Lak Shin Jeong، نويسنده , , Moon Woo Chun and، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
3499
To page
3501
Abstract
The pyrimidine nucleosides fused with 3′,4′-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene- -glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2′-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793597
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