Title of article
Synthesis and evaluation of tripeptidyl α-Ketoamides as human rhinovirus 3C protease inhibitors
Author/Authors
Shu-Hui Chen، نويسنده , , Jason Lamar، نويسنده , , Frantz Victor، نويسنده , , Nancy Snyder، نويسنده , , Robert Johnson، نويسنده , , Beverly A. Heinz، نويسنده , , Mark Wakulchik، نويسنده , , Q. May Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
3531
To page
3536
Abstract
We describe herein the synthesis and biological evaluation of a series of tripeptidyl α-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793604
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