Author/Authors :
Roger Léger، نويسنده , , Martin Robitaille، نويسنده , , Omar Quraishi، نويسنده , , Elizabeth Denholm، نويسنده , , Corinne Benquet، نويسنده , , Julie Carette، نويسنده , , Pieter van Wyk، نويسنده , , Isabelle Pellerin، نويسنده , , Nathalie Bousquet-Gagnon، نويسنده , , Jean-Paul Castaigne، نويسنده , , Dominique Bridon، نويسنده ,
Abstract :
Atrial natriuretic peptide (ANP) is a clinically useful anti-hypertensive hormone. Maleimide derivatives of ANP have been synthesized and conjugated to cysteine-34 of human serum albumin. The conjugates were analyzed to assess their stability, receptor binding affinity and ability to stimulate guanylyl-cyclase activity in rat lung fibroblasts.
