Title of article
Adenosine-anchored triphosphate subsite probing: distinguishing between HER-2 and HER-4 tyrosine protein kinases
Author/Authors
Fei Liu، نويسنده , , Eric F. Johnson، نويسنده , , David J. Austin، نويسنده , , Karen S. Anderson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
3587
To page
3592
Abstract
A strategy of full-site occupancy and stereospecific recognition in the triphosphate subsite was used to specifically inhibit two protein kinases HER-2 and HER-4 from the EGFR family. The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793616
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