Title of article :
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents
Author/Authors :
Nicholas J. Lawrence، نويسنده , , David Rennison، نويسنده , , Alan T. McGown، نويسنده , , John A. Hadfield، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC50 K562 50 nM) and caused significant G2/M cell-cycle arrest.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
