Author/Authors :
Brian Dyck، نويسنده , , Jessica Parker، نويسنده , , Teresa Phillips، نويسنده , , Lee Carter، نويسنده , , Brian Murphy، نويسنده , , Robin Summers، نويسنده , , Julia Hermann، نويسنده , , Tracy Baker، نويسنده , , Mary Cismowski، نويسنده , , John Saunders، نويسنده , , Val Goodfellow، نويسنده ,
Abstract :
Incorporation of substituted phenyl piperazine privileged structures into a known MC4 specific dipeptoid consensus sequence resulted in a series of potent (EC50=24 nM) and selective MC4-R agonists. We report the SAR of this series of compounds using in vitro cAMP functional assays in cells transfected with the MC4 or other melancortin receptors.
