Title of article
Synthesis and biological evaluation of 4-[(3-Methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor
Author/Authors
Nan-Horng Lin، نويسنده , , L.E. Wang، نويسنده , , Jerry Cohen، نويسنده , , Wen-Zhen Gu، نويسنده , , David Frost، نويسنده , , Haiying Zhang، نويسنده , , Saul Rosenberg، نويسنده , , Hing Sham، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
3821
To page
3825
Abstract
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anticancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analogue 11 that possesses potent enzymatic and cellular activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793666
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