Author/Authors :
Marcin Stasiak، نويسنده , , Christopher Mehlin، نويسنده , , Erica Boni، نويسنده , , Tomas Vaisar، نويسنده , , Thomas Little، نويسنده , , Hwa-Ok Kim، نويسنده , , Maher Qabar، نويسنده ,
Abstract :
The discovery of a sulphonamide by-product with VLA-4 antagonistic activity led to a series of potent, small molecule VLA-4 antagonists. Synthesis, SAR and in vivo evaluation of the selected compound will be presented.
