Author/Authors :
Ronald M. Baldwin، نويسنده , , Xing Fu، نويسنده , , Nora S. Kula، نويسنده , , Ross J. Baldessarini، نويسنده , , Louis Amici، نويسنده , , Robert B. Innis، نويسنده , , Gilles D. Tamagnan، نويسنده ,
Abstract :
The iodobenzamide neuroleptic analogue (S)-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-5-iodo-6-methoxybenzamide (5-IBZM) was synthesized stereospecifically and its pharmacological properties were compared with the 3-iodo isomer (IBZM) used for imaging D2 receptors in vivo. The isomer 5-IBZM had 100-fold lower affinity than IBZM and migrated with similar retention time as the byproduct formed during electrophilic iodination of BZM.
