Title of article
Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: coadministration with indinavir
Author/Authors
Nancy J. Kevin، نويسنده , , Joseph L. Duffy، نويسنده , , Brian A. Kirk، نويسنده , , Kevin T. Chapman، نويسنده , , William A. Schleif، نويسنده , , David B. Olsen، نويسنده , , Mark Stahlhut، نويسنده , , Carrie A. Rutkowski، نويسنده , , Lawrence C. Kuo، نويسنده , , Lixia Jin، نويسنده , , Jiunn H. Lin، نويسنده , , Emilio A. Emini، نويسنده , , James R. Tata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
4027
To page
4030
Abstract
HIV-1 protease inhibitors (PI) with an N-arylpyrrole moiety in the P3 position afforded excellent antiviral potency and substantially improved aqueous solubility over previously reported variants. The rapid in vitro clearance of these compounds in human liver microsomes prompted oral coadministration with indinavir to hinder their metabolism by the cyctochrome P450 3A4 isozyme and allow for in vivo PK assessment.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793711
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