Title of article
5-Amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H3]-methylsulfanyl-1H-pyrazole-4-carbonitrile (CTOM): Synthesis and Characterization of a Novel and Selective Insect GABA Receptor Radioligand
Author/Authors
Sanath K. Meegalla، نويسنده , , Dario Doller، نويسنده , , Gary M. Silver، نويسنده , , Nancy Wisnewski، نويسنده , , Richard M. Soll، نويسنده , , Dale Dhanoa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
4035
To page
4037
Abstract
Pyrazole 2a is a novel, potent ligand for insect GABA receptors obtained from housefly head membrane preparations (Ki=8 nM). It is 500-fold selective against the mammalian receptor (mouse brain preparations). Its specifically tritiated version (2b) was synthesized by reduction of disulfide 10 with NaBH4 followed by alkylation with [3H3]-CH3I.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793713
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