Title of article
Synthesis and antiproliferative activity of retroetoposide
Author/Authors
Philippe Meresse، نويسنده , , Prokopios Magiatis، نويسنده , , Emmanuel Bertounesque، نويسنده , , Claude Monneret، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
4107
To page
4109
Abstract
Retro-4′-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4′-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-β- -glucoside 26 afforded retroetoposide 5 which is 10-fold less cytotoxic than etoposide against L1210 cell line.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793728
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