Author/Authors :
Srinivas Nanduri، نويسنده , , Siva Sanjeeva Rao Thunuguntla، نويسنده , , Vijay Kumar Nyavanandi، نويسنده , , Sridevi Kasu، نويسنده , , P. Mahesh Kumar، نويسنده , , P. Sai Ram، نويسنده , , Sriram Rajagopal، نويسنده , , R. Ajaya Kumar، نويسنده , , Dhanvanthri S. Deevi، نويسنده , , R. Rajagopalan، نويسنده , , A. Venkateswarlu، نويسنده ,
Abstract :
Azadirone 1, a limonoidal constituent of Azadirachta indica is found to possess potent cytotoxic activity against a panel of human cancer cell lines in our in vitro studies. In vitro screening of a number of semi-synthetic analogues of 1 revealed that the α,β-unsaturated enone moiety or its equivalent conjugated system in A-ring, C-7 acetyloxy/chloroacetyloxy or keto group in B-ring and the furan moiety are responsible for the activity of 1 and its analogues. Compound 1 and two of the semi-synthetic analogues 10 and 13 were found to possess good in vivo antitumor activity in modified hollow fiber animal models.
