Author/Authors :
Michael B. Gravestock، نويسنده , , David G. Acton، نويسنده , , Michael J. Betts، نويسنده , , Michael Dennis، نويسنده , , Glenn Hatter، نويسنده , , Alexandra McGregor، نويسنده , , Michael L. Swain، نويسنده , , R. Geoffrey Wilson، نويسنده , , Lisa Woods، نويسنده , , Alan Wookey، نويسنده ,
Abstract :
Exploration of the structure–activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563.
