Author/Authors :
Karine Barral، نويسنده , , Robert C. Hider، نويسنده , , Jan Balzarini، نويسنده , , Johan Neyts، نويسنده , , Erik De Clercq، نويسنده , , Michel Camplo، نويسنده ,
Abstract :
We describe the synthesis and the antiviral evaluation of novel α and β dideoxynucleoside derivatives in which the base has been replaced by a 3-hydroxy-2-methylpyridin-4-one. The syntheses were successfully achieved by the use of the standard Vorbrüggen coupling conditions. Moderate activity of these compounds were found on herpes simplex virus (HSV) type 1 and type 2.
