Author/Authors :
John L. Kane Jr.، نويسنده , , Bradford H. Hirth، نويسنده , , Beirong Liang، نويسنده , , Brian B. Gourlie، نويسنده , , Sharon Nahill، نويسنده , , Gary Barsomian، نويسنده ,
Abstract :
Ureas of 5-aminopyrazole and 2-aminothiazole emerged as lead compounds from a high-throughput screen assaying the growth of Staphylococcus aureus. Structure–activity relationships were developed for each compound series. Several compounds were also tested for activity against drug resistant strains of S. aureus in vivo.
