Author/Authors :
Stephen P. East، نويسنده , , R. Paul Beckett، نويسنده , , Daniel C. Brookings، نويسنده , , John M. Clements، نويسنده , , Sheila Doel، نويسنده , , Kenneth Keavey، نويسنده , , Gilles Pain، نويسنده , , Helen K. Smith، نويسنده , , Wayne Thomas، نويسنده , , Alison J. Thompson، نويسنده , , Richard S. Todd، نويسنده , , Mark Whittaker، نويسنده ,
Abstract :
A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3′ amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.
Keywords :
Peptide deformylase , 111 MiltonPark , Antibacterial.* Corresponding author at present address: Evotec OAI , inhibitors , Oxon , Abingdon , OX14 4SD. Tel.: +44-1235-441416 , fax:+44-1235-441351 , e-mail: stephen.east@evotecoai.com
