Author/Authors :
Vedula M. Sharma، نويسنده , , K. V. Adi Seshu، نويسنده , , V. Chandra Sekhar، نويسنده , , Sachin Madan، نويسنده , , B. Vishnu، نويسنده , , P. Aravind Babu، نويسنده , , C. Vamsee Krishna، نويسنده , , J. Sreenu، نويسنده , , V. Ravi Krishna، نويسنده , , A. Venkateswarlu، نويسنده , , Sriram Rajagopal، نويسنده , , R. Ajaykumar، نويسنده , , T. Sravan Kumar، نويسنده ,
Abstract :
A new series of [4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl-amines was prepared and tested for its in vitro cytotoxic activity against a panel of 12 human cancer cell lines. Compounds 9, 15, 24 and 31 showed good in vitro activity and were further tested for their in vivo efficacy in the HT-29 human colon adeno carcinoma xenograft model. Compound 9 exhibited promising activity in this model. Dose–response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400 mg/kg doses were performed.
