Title of article
Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl)phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents
Author/Authors
Vedula M. Sharma، نويسنده , , K. V. Adi Seshu، نويسنده , , V. Chandra Sekhar، نويسنده , , Sachin Madan، نويسنده , , B. Vishnu، نويسنده , , P. Aravind Babu، نويسنده , , C. Vamsee Krishna، نويسنده , , J. Sreenu، نويسنده , , V. Ravi Krishna، نويسنده , , A. Venkateswarlu، نويسنده , , Sriram Rajagopal، نويسنده , , R. Ajaykumar، نويسنده , , T. Sravan Kumar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
67
To page
71
Abstract
A new series of [4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl-amines was prepared and tested for its in vitro cytotoxic activity against a panel of 12 human cancer cell lines. Compounds 9, 15, 24 and 31 showed good in vitro activity and were further tested for their in vivo efficacy in the HT-29 human colon adeno carcinoma xenograft model. Compound 9 exhibited promising activity in this model. Dose–response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400 mg/kg doses were performed.
Keywords
Orally active anti-cancer agents , HT-29 human colon adeno carcinomaxenograft.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793927
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