Author/Authors :
Gerardo D. Francisco، نويسنده , , Zhong Li، نويسنده , , J. Donald Albright، نويسنده , , Nancy H. Eudy، نويسنده , , Alan H. Katz، نويسنده , , Peter J. Petersen، نويسنده , , Pornpen Labthavikul، نويسنده , , Guy Singh، نويسنده , , Youjun Yang، نويسنده , , Beth A. Rasmussen، نويسنده , , Yang-I Lin، نويسنده , , Tarek S. Mansour، نويسنده ,
Abstract :
Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VRE and PRSP. 3,4-Difluorophenyl 5-cyanothiazolylurea (3p) with clog P of 2.64 demonstrated antibacterial activity against both gram-positive and gram-negative bacteria.
