Author/Authors :
Alberto Coelho، نويسنده , , Eddy Sotelo، نويسنده , , Nuria Fraiz، نويسنده , , Matilde Y??ez، نويسنده , , Reyes Laguna، نويسنده , , Ernesto Cano، نويسنده , , Enrique Ravi?a، نويسنده ,
Abstract :
A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)-pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring.
