Title of article
Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents
Author/Authors
Neetu Tewari، نويسنده , , V.K. Tiwari، نويسنده , , R.P Tripathi، نويسنده , , V. Chaturvedi، نويسنده , , A. Srivastava، نويسنده , , R. Srivastava، نويسنده , , P.K. Shukla، نويسنده , , A.K. Chaturvedi، نويسنده , , S. A. Gaikwad، نويسنده , , S. Sinha، نويسنده , , B.S. Srivastava، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
329
To page
332
Abstract
The galactopyranosyl amino alcohols (3–16) were synthesised by regioselective oxirane ring opening of compound 2 with variety of amines and screened for antitubercular and antifungal activities. One of the compounds (16) showed potent activity against Mycobacterium tuberculosis H37 Rv in vitro and also displayed activity in MDR TB. The compound (16) was found to be superior to ethambutol clinically used anti TB drug in in vitro screen.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793979
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