Title of article :
Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors
Author/Authors :
Toshio Nakamura ، نويسنده , , Hiroyuki Kakinuma، نويسنده , , Hiroki Umemiya، نويسنده , , Hideaki Amada، نويسنده , , Noriyuki Miyata، نويسنده , , Kazuo Taniguchi، نويسنده , , Kagumi Bando، نويسنده , , Masakazu Sato، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
In a previous paper, we reported that an imidazole derivative 1 exhibited a potent inhibitory activity of 20-HETE synthase (1; IC50 value of 5.7 nM), but this compound also exhibited little selectivity for cytochrome P450s (CYPs). We examined some derivatives of imidazole 1 which had an amino group on the side chain, and found that a dimethylaminohexyloxy derivative (3g; IC50 value of 8.8 nM) showed potent and selective inhibitory activity.
Keywords :
e-mail: toshio.nakamura@po.rd.taisho.co.jp , fax:+81-48-652-7254 , 20-HETE.* Corresponding author. Tel.:+81-48-669-3029
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
