Author/Authors :
Joanne M. Smallheer، نويسنده , , Carolyn A. Weigelt، نويسنده , , Francis J. Woerner، نويسنده , , Jennifer S. Wells، نويسنده , , Wayne F. Daneker، نويسنده , , Shaker A. Mousa، نويسنده , , Ruth R. Wexler، نويسنده , , Prabhakar K. Jadhav، نويسنده ,
Abstract :
Analogues of isoxazoline αvβ3 antagonist 1 designed to further restrict the four carbon alkyl tether were prepared by incorporating two spirocyclic scaffolds, 1-oxa-2-azaspiro[4,5]dec-2-ene and 1-oxa-2,7-diazaspiro[4,4]non-2-ene. Additional optimization provided potent antagonists of both αvβ3 and α5β1 which are selective over GPIIb/IIIa.
