Author/Authors :
Arturo Perez-Medrano، نويسنده , , Steven A. Buckner، نويسنده , , Michael J. Coghlan، نويسنده , , Robert J. Gregg، نويسنده , , Murali Gopalakrishnan، نويسنده , , Michael E. Kort، نويسنده , , John K. Lynch، نويسنده , , Victoria E. Scott، نويسنده , , James P. Sullivan، نويسنده , , Kristi L. Whiteaker، نويسنده , , William A. Carroll، نويسنده ,
Abstract :
Thiourea derivatives were identified as glyburide-reversible potassium channel openers through high-throughput screening. Based on these findings, a number of novel cyanoguanidines were designed and synthesized, which hyperpolarized human bladder KATP channels. These agents are potent full agonists in relaxing electrically-stimulated pig bladder strips. The synthesis, SAR and biological properties of these agents are discussed.
