Author/Authors :
Alcides J.M. da Silva، نويسنده , , Antonio L. Coelho، نويسنده , , Alessandro B.C. Simas، نويسنده , , Raphael A.M. Moraes، نويسنده , , Diogo A. Pinheiro، نويسنده , , Fabr??cio F.A. Fernandes، نويسنده , , Emerson Z. Arruda، نويسنده , , Paulo R.R. Costa، نويسنده , , Paulo A. Melo، نويسنده ,
Abstract :
Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group.
