Title of article :
Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors
Author/Authors :
Sunil K. Singh، نويسنده , , P.Ganapati Reddy، نويسنده , , K.Srinivasa Rao، نويسنده , , Braj B. Lohray، نويسنده , , P. Misra، نويسنده , , Shaikh A. Rajjak، نويسنده , , Yeleswarapu K. Rao، نويسنده , , A. Venkateswarlu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Several chemical modifications in the N1-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro.
Keywords :
1 , Benzenesulfonamide , 5-Diarylpyrazoles , COX-2 inhibitors. , Polar substitutions
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
