3-(4-Aminobutyn-1-yl)pyridines: binding at α4β2 nicotinic cholinergic receptors

The binding of a series pyridylbutynylamines 6 was examined at α4β2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models.