Binding of an imidazopyridoindole at imidazoline I2 receptors

3,5,6,11-Tetrahydro-2H-imidazo[1′,2′:1,2]pyrido[3,4-b]indole (10) might be viewed as a fusion structure of two classes of I2 imidazoline receptor ligands: 2-(2-benzofuranyl)-2-imidazolines and β-carbolines. Its high affinity (Ki=7.3 nM) provides insight to how the two classes of agents might bind relative to one another at I2 receptors.