Author/Authors :
Dmitry O. Koltun، نويسنده , , Timothy A. Marquart، نويسنده , , Kevin D. Shenk، نويسنده , , Elfatih Elzein، نويسنده , , Yuan Li، نويسنده , , Marie Nguyen، نويسنده , , Suresh Kerwar، نويسنده , , Dewan Zeng، نويسنده , , Nancy Chu، نويسنده , , Daniel Soohoo، نويسنده , , Jia-Hao Chang، نويسنده , , Victoria Y. Maydanik، نويسنده , , David A. Lustig، نويسنده , , Khing-Jow Ng، نويسنده , , Heather Fraser، نويسنده , , Jeffery A. Zablocki، نويسنده ,
Abstract :
New inhibitors of palmitoylCoA oxidation were synthesized based on a structurally novel lead, CVT-3501 (1). Investigation of structure–activity relationships was conducted with respect to potency of inhibition of cardiac mitochondrial palmitoylCoA oxidation and metabolic stability. Potent and metabolically stable analogues 33, 42, and 43 were evaluated in vitro for cytochrome P450 inhibition and potentially adverse electrophysiological effects. Compound 33 was also found to have favorable pharmacokinetic properties in rat.
