Title of article :
Structure–activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists
Author/Authors :
Gregory A. Gfesser، نويسنده , , X. Henry Zhang، نويسنده , , Jurgen Dinges، نويسنده , , Gerard B. Fox، نويسنده , , Jia Bao Pan، نويسنده , , Timothy A. Esbenshade، نويسنده , , Betty B. Yao، نويسنده , , David Witte، نويسنده , , Thomas R. Miller، نويسنده , , Chae-Hee Kang، نويسنده , , Kathy M. Krueger، نويسنده , , Youssef L. Bennani، نويسنده , , Arthur A. Hancock، نويسنده , , Ramin Faghih، نويسنده ,
Abstract :
Further SAR studies on novel histamine H3 receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model.
