Title of article :
Thiazoles and thiopyridines: novel series of high affinity h5HT7 ligands
Author/Authors :
Christopher G. Thomson، نويسنده , , Margaret S. Beer، نويسنده , , Neil R. Curtis، نويسنده , , Helen J. Diggle، نويسنده , , Emma Handford، نويسنده , , Janusz J. Kulagowski، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of thiazole based 5HT7 ligands has been identified from screening. Optimisation of the pendent aryl group and modification of the core gave a related series of high affinity, selective thiopyridine based 5HT7 ligands, the most active of which behaves as a partial agonist.
Keywords :
Thiopyridines , Partial agonist.* Corresponding author. Tel.: +44-1279-440563 , fax: +44-1279- , h5HT7 ligands , thiazoles
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
