Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases

Peptidyl aldehydes were tested for inhibition of dual-specificity phosphatases VH1 and VHR. The most potent compound, cinnamaldehyde–Gly–Glu–Glu (Cinn–GEE), acted as a slow-binding inhibitor with KI* values of 18 and 288 μM against VH1 and VHR, respectively.