Author/Authors :
John G. Catalano، نويسنده , , David N. Deaton، نويسنده , , Stacey T. Long، نويسنده , , Robert B. McFadyen، نويسنده , , Larry R. Miller، نويسنده , , J.Alan Payne، نويسنده , , Kevin J. Wells-Knecht، نويسنده , , Lois L. Wright، نويسنده ,
Abstract :
A novel series of ketoamide-based inhibitors of cathepsin K has been identified. Modifications to P2 and P3 elements were crucial to enhancing inhibitory activity. Although not optimized, a selected inhibitor was effective in attenuating type I collagen hydrolysis in a surrogate assay of bone resorption.
