Title of article
Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia
Author/Authors
Taiwei Chu، نويسنده , , Shaowen Hu، نويسنده , , Bing Wei، نويسنده , , Yi Wang، نويسنده , , Xinqi Liu، نويسنده , , Xiangyun Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
747
To page
749
Abstract
1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N4IPA) was synthesized. The biodistribution of 99mTc-N4IPA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that 99mTc-N4IPA would be a marker for imaging tumor hypoxia.
Keywords
4-Nitroimidazole , biodistribution , Hypoxia Imaging Agent , Tumor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794067
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