Author/Authors :
Bin Ye، نويسنده , , Yuo-Ling Chou، نويسنده , , Rushad Karanjawala، نويسنده , , Wheeseong Lee، نويسنده , , Shou-Fu Lu، نويسنده , , Kenneth J. Shaw، نويسنده , , Steven Jones، نويسنده , , Dao Lentz، نويسنده , , Amy Liang، نويسنده , , Jih-Lie Tseng، نويسنده , , Qingyu Wu، نويسنده , , Zuchun Zhao، نويسنده ,
Abstract :
Compound 2 was identified by high throughput screening as a novel PAI-1 inhibitor. Systematic optimization of the A, B, and C segments of 2 resulted in the identification of a more potent compound 39 with good oral bioavailability. The synthesis and SAR data are presented in this report.
