Author/Authors :
Hyeung-geun Park، نويسنده , , Ji-yeon Choi، نويسنده , , Sea-hoon Choi، نويسنده , , Mi-kyung Park، نويسنده , , Jihye Lee، نويسنده , , Young-Ger Suh، نويسنده , , Hawon Cho، نويسنده , , Uhtaek Oh، نويسنده , , Jiyoun Lee، نويسنده , , Sang Uk Kang، نويسنده , , Jeewoo Lee، نويسنده , , Hee-Doo Kim، نويسنده , , Young-Ho Park، نويسنده , , Yeon Su Jeong، نويسنده , , Jin Kyu Choi، نويسنده , , Sang-sup Jew، نويسنده ,
Abstract :
A series of N-4-substituted-benzyl-N′-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG neurons. Their structure–activity relationship reveals that not only the two oxygens and amide hydrogen of sulfonamido group, but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor.
