Author/Authors :
William G. Harter، نويسنده , , Hans Albrect، نويسنده , , Kenneth Brady، نويسنده , , Bradley Caprathe، نويسنده , , James Dunbar، نويسنده , , John Gilmore، نويسنده , , Sheryl Hays، نويسنده , , Catherine R. Kostlan، نويسنده , , Beth Lunney، نويسنده , , Nigel Walker، نويسنده ,
Abstract :
A series of sulfonamides (1) has been prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase 1. These compounds were designed to improve potency by rigidifying the enzyme bound molecule through an intramolecular hydrogen bond. An X-ray crystal structure of a representative member of this series bound to the active site of ICE, confirms the presence of the hydrogen bonding interaction.
