Title of article
Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate
Author/Authors
Noriyuki Maeda، نويسنده , , Yoshito Takeuchi، نويسنده , , Miki Takada، نويسنده , , Yukihiro Namba، نويسنده , , Naoto Oku، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
1015
To page
1017
Abstract
For the purpose of cancer antineovascular therapy, a novel angiogenesis-targeted peptide, Ala-Pro-Arg-Pro-Gly, (APRPG) was attached to hydrophobized polyethylene glycol (distearoylphosphatidylethanolamine [DSPE]-PEG). DSPE-PEG and the 5-mer peptide were condensed with DCC-HOBt method. Liposome modified with this DSPE-PEG-APRPG conjugate highly accumulated in tumor of tumor-bearing mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794121
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