Title of article :
4-Substituted anilides as selective melatonin MT2 receptor agonists
Author/Authors :
James R. Epperson، نويسنده , , Jeffrey A. Deskus، نويسنده , , Anthony J. Gentile، نويسنده , , Lawrence G. Iben، نويسنده , , Elaine Ryan، نويسنده , , Nathan S. Sarbin، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT2 binding affinity and MT2 selectivity of at least 70-fold over the MT1 receptor. Compound 26 demonstrated full agonism at the MT2 receptor.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
