• Title of article

    4-Substituted anilides as selective melatonin MT2 receptor agonists

  • Author/Authors

    James R. Epperson، نويسنده , , Jeffrey A. Deskus، نويسنده , , Anthony J. Gentile، نويسنده , , Lawrence G. Iben، نويسنده , , Elaine Ryan، نويسنده , , Nathan S. Sarbin، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2004
  • Pages
    4
  • From page
    1023
  • To page
    1026
  • Abstract
    A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT2 binding affinity and MT2 selectivity of at least 70-fold over the MT1 receptor. Compound 26 demonstrated full agonism at the MT2 receptor.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2004
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    794123

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=794123