Author/Authors :
Lawrence G. Hamann، نويسنده , , Charles Z. Ding، نويسنده , , Arthur V. Miller، نويسنده , , Cort S. Madsen، نويسنده , , Paulina Wang، نويسنده , , Philip D. Stein، نويسنده , , Andrew T. Pudzianowski، نويسنده , , David W. Green، نويسنده , , Hossain Monshizadegan، نويسنده , , Karnail S. Atwal، نويسنده ,
Abstract :
A series of benzodiazepine-based inhibitors of mitochondrial F1F0 ATP hydrolase were prepared and evaluated for their ability to selectively inhibit the enzyme in the forward direction. Compounds from this series showed excellent potency and selectivity for ATP hydrolase versus ATP synthase, suggesting a potentially beneficial profile useful for the treatment of ischemic heart disease.
Keywords :
Mitochondrial ATP hydrolase , ischemia , Heart disease.* Corresponding author. Tel.: +1-609-818-5526 , fax: +1-609-818-
