Title of article
Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists
Author/Authors
Robin D. Clark، نويسنده , , Alam Jahangir، نويسنده , , Daniel Severance، نويسنده , , Rick Salazar، نويسنده , , Thomas Chang، نويسنده , , David Chang، نويسنده , , Mary Frances Jett، نويسنده , , Steven Smith، نويسنده , , Keith Bley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1053
To page
1056
Abstract
On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl]amine] had analgesic activity in the rat.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794130
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