Author/Authors :
Robin D. Clark، نويسنده , , Alam Jahangir، نويسنده , , Daniel Severance، نويسنده , , Rick Salazar، نويسنده , , Thomas Chang، نويسنده , , David Chang، نويسنده , , Mary Frances Jett، نويسنده , , Steven Smith، نويسنده , , Keith Bley، نويسنده ,
Abstract :
On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl]amine] had analgesic activity in the rat.
