Title of article
Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models
Author/Authors
Atul Goel، نويسنده , , Nidhi Agarwal، نويسنده , , Fateh V. Singh، نويسنده , , Ashoke Sharon، نويسنده , , Priti Tiwari، نويسنده , , Manish Dixit، نويسنده , , Ramendra Pratap، نويسنده , , Arvind K. Srivastava، نويسنده , , Prakas R. Maulik، نويسنده , , Vishnu J. Ram، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1089
To page
1092
Abstract
Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794136
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