Author/Authors :
Atul Goel، نويسنده , , Nidhi Agarwal، نويسنده , , Fateh V. Singh، نويسنده , , Ashoke Sharon، نويسنده , , Priti Tiwari، نويسنده , , Manish Dixit، نويسنده , , Ramendra Pratap، نويسنده , , Arvind K. Srivastava، نويسنده , , Prakas R. Maulik، نويسنده , , Vishnu J. Ram، نويسنده ,
Abstract :
Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model.
